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EFFECT OF RESERPINE PRETREATMENT ON THE RESPONSE OF ISOLATED PAPILLARY MUSCLE TO EPHEDRINE
Author(s) -
CAIROLI V. J.,
REILLY J. F.,
ROBERTS J.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01177.x
Subject(s) - reserpine , papillary muscle , ephedrine , inotrope , medicine , endocrinology , chemistry , cats , contraction (grammar) , in vivo , pharmacology , biology , microbiology and biotechnology
Reserpine pretreatment of cats abolished the action of ephedrine to induce spontaneous beating in papillary muscles obtained from these animals. This spontaneous beating was viewed as resulting solely from catechol amine release. The positive inotropic action of ephedrine was diminished but not abolished by reserpine pretreatment. Reserpine reduced the heart rate in vivo , but it did not affect the peak contraction height or the rate of failure of the isolated papillary muscle. The contractile response to adrenaline (0.1 μg/ml.) was not affected by reserpine pretreatment. However, in this concentration adrenaline induced spontaneous beating only after reserpine.