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RELATION IN RAT HIND‐LIMB BLOOD VESSELS BETWEEN NERVOUS VASOMOTOR TONE AND THE RESPONSE TO VASOCONSTRICTOR DRUGS
Author(s) -
LAVERTY R.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01167.x
Subject(s) - hindlimb , reserpine , vasomotor , endocrinology , sympathetic nervous system , medicine , blood vessel , blood pressure , tyramine , norepinephrine , anatomy , dopamine
When the nervous component of the vasomotor tone of the blood vessels of the innervated rat hind limb perfused with blood was reduced by ganglion blockade, by section of the nerves to the hind limb, or by the indirect effect of drugs, the vasoconstrictor response of the blood vessels to noradrenaline was immediately increased. This increased peripheral response was observed only when the blood perfusing the hind limb was from the same animal or from a genetically similar animal. Reduction of the nervous component of the vasomotor tone also increased the constrictor response of the hind‐limb blood vessels to adrenaline, ephedrine, tyramine and 5‐hydroxytryptamine, but did not increase the response to angiotensin, vasopressin or S‐methyl iso thiourea. Pre‐treatment with reserpine increased the hind‐limb response to noradrenaline but reduced the response to ephedrine, tyramine and 5‐hydroxytryptamine. The results suggest that, in rats, activity in the sympathetic nervous system directly influences the reactivity of peripheral blood vessels to noradrenaline and other sympathomimetic drugs.