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ACTIONS OF BRETYLIUM AND GUANETHIDINE ON THE UPTAKE AND RELEASE OF [ 3 H]‐NORADRENAUNE
Author(s) -
HERTTING G.,
AXELROD J.,
PATRICK R. W.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01159.x
Subject(s) - bretylium , guanethidine , reserpine , liberation , chemistry , endocrinology , medicine , free nerve ending , stimulation , norepinephrine , iproniazid , pharmacology , adrenergic , dopamine , biochemistry , monoamine oxidase , enzyme , receptor , in vitro
The effect of bretylium and guanethidine has been studied on the uptake and the spontaneous and reserpine‐induced release of [ 3 H]‐noradrenaline in the rat heart and in the splenic nerve endings of the cat. Bretylium and guanethidine inhibited the uptake by the heart of circulating [ 3 H]‐noradrenaline. Bretylium blocked spontaneous and reserpine‐induced release of [ 3 H]‐noradrenaline, while guanethidine caused release and partially antagonized the reserpine‐induced release. Both compounds produced a transient liberation of [ 3 H]‐noradrenaline from splenic nerves, but blocked the release of the [ 3 H]‐catechol amine following stimulation of the splenic nerve.