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ON THE METABOLISM OF METHYLATED DISULPHONAMIDES WITH A DIURETIC ACTION—A CONTRIBUTION TO THE MECHANISM OF ACTION OF CHLOROTHIAZIDE AND SIMILAR COMPOUNDS
Author(s) -
LOGEMANN W.,
GIRALDI P. N.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01150.x
Subject(s) - chlorothiazide , diuretic , carbonic anhydrase , chemistry , mechanism of action , metabolism , acetazolamide , pharmacology , enzyme , benzothiadiazines , biochemistry , medicine , in vitro
The metabolism of two substances possessing a diuretic action, 4‐amino‐6‐chloro‐benzene‐1,3‐disulphonmethylamide (III) and 6‐chloro‐3,4‐dihydro‐2‐methyl‐7‐methyl‐sulphamoyl‐2 H ‐1,2,4‐benzo[ e ]thiadiazine‐1,1‐dioxide (IV), has been studied on rats and human subjects. It has been shown that these compounds are not demethylated in the –SO 2 .NHCH 3 group. They therefore do not act through liberation of substances with unsubstituted sulphonamido‐groups which might inhibit carbonic anhydrase, and their mechanism of diuretic action cannot be considered due to inhibition of this enzyme.