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INCREASE OF PENTOBARBITONE METABOLISM INDUCED IN RATS PRETREATED WITH SOME CENTRALLY ACTING COMPOUNDS
Author(s) -
KATO R.,
CHIESARA E.
Publication year - 1962
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1962.tb01147.x
Subject(s) - meprobamate , glutethimide , metabolism , chlorpromazine , pentobarbital , chemistry , ethionine , pharmacology , barbiturate , drug metabolism , phenobarbital , medicine , biochemistry , amino acid , methionine
Rats treated with phenobarbitone, phenaglycodol, glutethimide, nikethamide, meprobamate, chlorbutol and chlorpromazine showed an increased metabolism of pentobarbitone and, at the same time, a diminished sleeping‐time after pentobarbitone. This effect developed 24 hr after treatment, the maximum increase in metabolism occurring after about 48 hr. The increased pentobarbitone metabolism was inhibited by ethionine injected shortly before treatment. Using a liver slice, preparation, increased pentobarbitone metabolism was also observed in vitro . These results are in accord with the view that the capacity of compounds to increase pentobarbitone metabolism may be related to their ability to act directly on microsomal enzyme systems.