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SOME EFFECTS OF A MONOAMINE OXIDASE INHIBITOR UPON CHANGES PRODUCED BY CENTRALLY ADMINISTERED AMINES
Author(s) -
SCHAIN R. J.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01286.x
Subject(s) - monoamine oxidase inhibitor , monoamine oxidase , tryptamine , cats , dopamine , pharmacology , monoamine neurotransmitter , tranylcypromine , serotonin , chemistry , subcutaneous injection , medicine , norepinephrine , endocrinology , biochemistry , enzyme , receptor
In cats treated with subcutaneous or intraperitoneal injections of the monoamine oxidase inhibitor phenylisopropylhydrazine, the effects of 5‐hydroxytryptamine injected into the lateral cerebral ventricle were greatly intensified and prolonged; the effects of adrenaline were potentiated to a lesser extent. Those of noradrenaline, dopamine and tryptamine were not intensified and were prolonged to only a slight degree.