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INTERACTIONS OF SYMPATHOMIMETIC DRUGS AND THEIR ANTAGONISTS ON THE ISOLATED ATRIUM
Author(s) -
BENFEY B. G.,
GREEFF K.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01283.x
Subject(s) - phenoxybenzamine , guanethidine , tyramine , sympathomimetics , sympatholytics , atrium (architecture) , pharmacology , vagus nerve , adrenergic , chemistry , norepinephrine , epinephrine , stimulation , medicine , endocrinology , propranolol , dopamine , receptor , atrial fibrillation
In the isolated guinea‐pig atrium, phenoxybenzamine and other antagonists of sympathomimetic drugs and the adrenergic nerve blocking agent guanethidine inhibited the action of butyrylcholine and tyramine and potentiated the action of noradrenaline. Also in the isolated guinea‐pig atrium, phenoxybenzamine and cocaine abolished the parasympathetic, and potentiated the sympathetic, effects of vagus stimulation.