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SYNTHETIC OXYTOCIN AS AN ANTAGONIST OF EXPERIMENTAL CARDIAC ANOXIC CHANGES IN RABBITS
Author(s) -
MELVILLE K. I.,
VARMA D. R.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01281.x
Subject(s) - oxytocin , picrotoxin , ergometrine , vasopressin antagonists , antagonist , vasopressin , medicine , ventricle , oxytocin receptor , anesthesia , endocrinology , receptor
Synthetic oxytocin (Syntocinon) can be shown to reduce or abolish ST‐T changes induced experimentally by hypoxaemia alone, by hypoxaemia and ergometrine, by vasopressin, and by a new procedure involving injection of small doses of picrotoxin into the lateral cerebral ventricle. Ventricular fibrillation induced by picrotoxin can also be reversed by oxytocin. These effects suggest a probable metabolic action of oxytocin against cardiac anoxic changes, and its possible therapeutic usefulness as an antagonist of myocardial ischaemia. It is speculated that this might be a physiological action of the hormone.