Premium
ON THE QUESTION OF THE OCCURRENCE AND METABOLISM OF 5‐HYDROXYTRYPTAMINE AND RELATED INDOLE COMPOUNDS IN MAMMALIAN SEMEN
Author(s) -
MANN T.,
SEAMARK R. F.,
SHARMAN D. F.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01280.x
Subject(s) - semen , tryptamine , incubation , tryptophan , uterus , serotonin , indole test , chemistry , metabolism , sperm , tyramine , endocrinology , biochemistry , biology , medicine , andrology , anatomy , receptor , amino acid
The content of 5‐hydroxytryptamine was examined in the semen of man, bull, ram, boar and dog. Spectrophotofluorimetric and chromatographic analysis of extracts prepared by several methods has shown that the semen contains only minute quantities of 5‐hydroxytryptamine, if any. One cannot attribute to 5‐hydroxytryptamine the uterus‐stimulating effect which the human seminal plasma is known to exert. Tryptophan, although present in the seminal plasma, is not converted to 5‐hydroxytryptamine on incubation of semen. 5‐Hydroxytryptophan is oxidatively deaminated, but not decarboxylated, by spermatozoa. 5‐Hydroxytryptamine itself, like tryptamine and tyramine, is not deaminated by either whole semen or washed suspensions of ram spermatozoa.