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TOXICOLOGICAL AND PHARMACOLOGICAL EFFECTS OF GADOLINIUM AND SAMARIUM CHLORIDES
Author(s) -
HALEY T. J.,
RAYMOND K.,
KOMESU N.,
UPHAM H. C.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01139.x
Subject(s) - ingestion , irritation , medicine , toxicity , pharmacology , gadolinium , anesthesia , inhalation , median lethal dose , physiology , toxicology , chemistry , biology , immunology , organic chemistry
A study has been made of the toxicology and pharmacology of gadolinium and samarium chlorides. The symptoms of acute toxicity following intraperitoneal injection are described. The chronic oral ingestion of both chemicals for 12 weeks produced no effects on growth or the blood picture, and only the male rats receiving gadolinium chloride showed liver damage. The pharmacological responses to both chemicals were mainly depressant on all systems studied, and death was associated with cardiovascular collapse coupled with respiratory paralysis. The greatest damage seen was on abraded skin, where non‐healing ulcers were produced by both chemicals, whereas irritation of intact skin and ocular tissues was only transient in nature.