Premium
DIURESIS IN RATS: EFFECTS OF SYMPATHOMIMETIC AND SYMPATHETIC BLOCKING AGENTS
Author(s) -
GREEN A. F.,
SIM M. F.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01133.x
Subject(s) - bretylium , phenoxybenzamine , chemistry , diuresis , medicine , tyramine , endocrinology , diuretic , adrenal medulla , sympathomimetics , antidiuretic , norepinephrine , sympatholytics , sympatholytic , adrenergic , sodium , dopamine , pharmacology , catecholamine , kidney , receptor , hormone , blood pressure , organic chemistry
Dopamine and tyramine possess diuretic properties resembling but weaker than those of noradrenaline in the rat. These three amines produce a relatively smaller loss of sodium than does adrenaline. Bretylium shows a diuretic action which is apparently associated with its sympathomimetic properties and which is antagonized by phenoxybenzamine. However, bretylium causes a relatively greater loss of potassium and chloride than do the sympathomimetic amines. A slight antidiuretic action is shown by bretylium after its diuretic effect has subsided and a similar effect is produced by BW 172C58, which has relatively weak sympathomimetic properties. In contrast to these adrenergic neurone blocking agents, phenoxybenzamine and a ganglion blocking agent (pentacynium) show powerful antidiuretic effects. These observations are consistent with the view that the adrenal medulla has an important role in facilitating water diuresis in rats.