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EXCRETION OF ANTIBIOTICS IN BILE
Author(s) -
HARRISON PATRICIA M.,
STEWART G. T.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01128.x
Subject(s) - benzylpenicillin , neomycin , penicillin , antibiotics , streptomycin , chloramphenicol , chemistry , excretion , urine , bile acid , microbiology and biotechnology , pharmacology , biochemistry , biology
The excretion of antibiotics in the bile of rats has been studied. Penicillins, including derivatives of 6‐aminopenicillanic acid, are rapidly excreted, reabsorbed and re‐excreted, in high concentration, whereas streptomycin, neomycin, paramomycin and chloramphenicol reach lower levels in the bile than in the plasma. p‐Aminobenzylpenicillin and d (—)‐6‐(α‐amino‐α‐phenylacetamido)penicillanic acid, both of which are bactericidal to Salmonellae and other conforms, produce higher concentrations in the bile than benzylpenicillin (penicillin G). This may be of therapeutic importance.