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THE RESERPINE‐TREATED CAT
Author(s) -
WITHRINGTON P.,
ZAIMIS ELEANOR
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01124.x
Subject(s) - reserpine , cats , isoprenaline , blood pressure , contraction (grammar) , medicine , peripheral , blood flow , cardiac output , heart failure , anesthesia , cardiology , stimulation
In cats, 24 hr after the administration of 1 mg/kg of reserpine, it was found that ( a ) the heart is in failure; ( b ) the sensitivity of the peripheral vessels to adrenaline, noradrenaline and isoprenaline, administered intravenously or close‐arterially, is decreased; ( c ) any blood pressure changes are, as a rule, secondary to changes in heart contraction; and ( d ) the peripheral blood flow passively follows the blood pressure changes. Furthermore, any improvement of the circulation at this stage was found to be almost exclusively the result of an amelioration in the force of cardiac contraction.