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ANTHELMINTIC ACTIVITY OF METHYRIDINE AGAINST EXPERIMENTAL NEMATODE INFECTIONS IN MICE
Author(s) -
BROOME A. W. J.,
GREENHALGH N.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01119.x
Subject(s) - anthelmintic , nematode , helminths , biology , medicine , immunology , physiology , veterinary medicine , ecology
Critical studies using mice infected experimentally with nematodes ( Nematospiroides dubius, Nippostrongylus muris and Heterakis spumosa ) have shown methyridine to be an extremely effective anthelmintic when administered orally or subcutaneously. Comparisons of the two treatment regimes show subcutaneous administration to be the more efficient in terms of absolute dose, but neither treatment has a significant advantage in therapeutic safety margin. Methyridine has a more uniform anthelmintic action than either phenothiazine or bephenium against adult forms of the three test nematodes. In addition the drug possesses activity against all stages of certain immature nematode infections.