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THE NEUROMUSCULAR BLOCKING ACTION OF γ‐OXALOLAUDONIUM BROMIDE
Author(s) -
BRITTAIN R. T.,
COLLIER H. O. J.,
D'ARCY P. F.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01111.x
Subject(s) - neostigmine , decamethonium , curare , paralysis , flaccid paralysis , neuromuscular transmission , anesthesia , medicine , potency , histamine , pharmacology , chemistry , acetylcholine , surgery , biochemistry , in vitro
In small animals gamma-oxalolaudonium caused flaccid paralysis; in the cat it produced a curare-like rather than a decamethonium-like block of neuromuscular transmission. The potency of gamma-oxalolaudonium was only 1/30 to 1/40 that of suxamethonium, but the duration of paralysis was very short, being about one-half that of equiactive doses of suxamethonium. Successive doses of gamma-oxalolaudonium were not cumulative and the paralysis could be antagonized by neostigmine. gamma-Oxalolaudonium exhibited low toxicity especially in artificially ventilated animals, and it did not show ganglionblocking or histamine-releasing activity to any large degree.