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ANALGESIC‐ANTIPYRETIC DRUGS AS INHIBITORS OF KALLIKREIN
Author(s) -
NORTHOVER B. J.,
SUBRAMANIAN G.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01110.x
Subject(s) - kallikrein , bradykinin , kallidin , pharmacology , analgesic , antipyretic , histamine , intradermal injection , chemistry , guinea pig , medicine , kinin , endocrinology , immunology , biochemistry , enzyme , receptor
The production of kallidin from guinea‐pig and ox serum kallidinogen by the action of guinea‐pig serum‐kallikrein or human salivary kallikrein was inhibited by various analgesic‐antipyretic drugs. This effect was obtained in vitro with concentrations of inhibitors which do not inhibit the smooth‐muscle‐stimulating action of the various polypeptides, but similar to the concentrations needed in vivo to obtain an anti‐inflammatory action. The vasodepressor action of intravenously administered human salivary kallikrein in the anaesthetized dog was very markedly inhibited by the intravenous administration of doses of various analgesic‐antipyretic drugs which only partially antagonized the responses to kallidin and bradykinin and which left the vasodepressor responses to histamine, acetylcholine and 5‐hydroxytryptamine unaffected. In rabbits the accumulation of protein‐bound dye at the site of intradermal injection of human salivary kallikrein and guinea‐pig serum‐kallikrein, but not of bradykinin and kallidin, was inhibited very markedly by the systemic administration of various analgesic‐antipyretic drugs.