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COMPARISON OF THE FUNCTIONAL EFFECTS OF DYFLOS, TRI‐O‐CRESYL PHOSPHATE AND TRI‐ p ‐ETHYLPHENYL PHOSPHATE IN CHICKENS
Author(s) -
CAVANAGH J. B.,
DAVIES D. R.,
HOLLAND P.,
LANCASTER M.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01100.x
Subject(s) - phosphate , chemistry , cholinesterase , endocrinology , pharmacology , medicine , biochemistry
Tri‐ p ‐ethylphenyl phosphate is unique amongst the organophosphorous compounds which produce neurotoxic effects in not being an inhibitor of cholinesterase. The dysfunction it produces is also marked by some unusual features. Thus it produces a characteristic high‐stepping gait which develops at varying periods after intramuscular injection but more regularly following oral administration. A careful comparison of the character, onset and development of the effects of diisopropyl phosphorofluoridate (dyflos), tri‐ o ‐cresyl phosphate and tri‐ p ‐ethylphenyl phosphate has illustrated the differences between the two former substances and tri‐ p ‐ethylphenyl phosphate. It has also confirmed a previous suggestion that this substance acts in a different manner from the other two, a suggestion supported by the histological evidence.