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SUPPRESSION OF OUABAIN‐INDUCED ATRIAL ARRHYTHMIAS BY CAROTID SINUS STIMULATION
Author(s) -
SCHOTT A.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01099.x
Subject(s) - stimulation , ouabain , cardiology , carotid sinus , medicine , atrial flutter , aconitine , digitalis , anesthesia , tachycardia , atrial tachycardia , atrial fibrillation , reflex , chemistry , pharmacology , heart failure , catheter ablation , organic chemistry , sodium
In dogs anaesthetized with chloralose ectopic atrial arrhythmias were produced by subepicardial injection of ouabain. Stimulation of the right carotid sinus abruptly suppressed the ectopic arrhythmias. They returned on cessation of stimulation and sometimes already during the period of stimulation. It is suggested that in view of its response to carotid sinus stimulation the ouabain‐induced arrhythmia resembles paroxysmal atrial tachycardia and that it is distinct from the aconitine‐induced arrhythmia which on account of its response to vagal stimulation has been classified as atrial flutter.