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UPTAKE OF LABELLED NORADRENALINE BY ISOLATED ATRIA
Author(s) -
BURN G. P.,
BURN J. H.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01094.x
Subject(s) - tyramine , intracellular , outflow , extracellular , medicine , chemistry , endocrinology , norepinephrine , atrium (architecture) , biology , biochemistry , dopamine , physics , meteorology , atrial fibrillation
The uptake of labelled noradrenaline by isolated rabbit atria has been studied, and the rate of outflow of radioactivity after a period of loading has been recorded. There is first a rapid outflow presumably from extracellular space, followed by a slow outflow presumably from intracellular space. Cocaine greatly diminished the intracellular uptake. Tyramine caused an increased outflow of radioactivity from intracellular sites which was not due to the increase in atrial rate, since noradrenaline which increased the rate more than tyramine had less effect on the outflow.