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POTENTIATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE IN VIVO
Author(s) -
KRIVOY W. A.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01084.x
Subject(s) - lysergic acid diethylamide , lysergic acid , pharmacology , long term potentiation , chemistry , in vivo , dorsum , hallucinogen , serotonin , biochemistry , medicine , biology , anatomy , receptor , microbiology and biotechnology
In doses of 10 μg/kg or more, lysergic acid diethylamide enhanced the fourth potential (DR IV) of the dorsal root potential complex in the cat. Smaller doses of lysergic acid diethylamide did not in themselves alter the DR IV, but revealed an enhancement of the potential by substance P, which by itself had no effect. 2‐Bromolysergic acid diethylamide had no action on the dorsal root potentials, but prevented the actions of lysergic acid diethylamide.