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LOCALIZATION OF CHOLINESTERASES IN THE CHICKEN NERVOUS SYSTEM AND THE PROBLEM OF THE SELECTIVE NEUROTOXICITY OF ORGANOPHOSPHORUS COMPOUNDS
Author(s) -
CAVANAGH J. B.,
HOLLAND P.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb01081.x
Subject(s) - cholinesterase , neurotoxicity , spinal cord , chemistry , nervous system , neuroscience , pharmacology , toxicology , biochemistry , toxicity , biology , organic chemistry
Using the thiocholine method, a restricted survey has been made of cholinesterases in the spinal cord and brain stem of the chicken. No simple relation between sites of selective damage in organophosphorus neurotoxicity and centres of cholinesterase activity could be adduced. Moreover, no significant differences between species susceptible and insusceptible to poisoning by these compounds were found by this method. It is concluded that, while cholinesterase may well play an intermediary role in the intoxication, other factors determine the selective damage to certain neurones and their processes.