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SOME INHIBITORS OF HISTAMINE‐INDUCED AND FORMALDEHYDE‐INDUCED INFLAMMATION IN MICE
Author(s) -
NORTHOVER B. J.,
SUBRAMANIAN G.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb00309.x
Subject(s) - histamine , sodium salicylate , inflammation , mepyramine , chemistry , pharmacology , formaldehyde , vascular permeability , cortisone , intradermal injection , immunology , endocrinology , medicine , biochemistry , receptor , antagonist
The swelling and capillary hyperpermeability of the mouse foot in response to an injection of formaldehyde, and the increased capillary permeability to an intradermal injection of histamine, have been investigated. Cortisone, mepyramine and sodium salicylate were effective in reducing histamine‐induced inflammation, sodium salicylate being less active in the adrenalectomized animal. In formaldehyde‐induced inflammation, however, cortisone was ineffective whereas sodium salicylate was effective in the intact mouse, but not in the adrenalectomized animal. Certain aryloxypropionates and anti‐esterases were also active in reducing the severity of the formaldehyde‐induced inflammation.