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EFFECT OF ANTIBIOTICS ON THE 5‐HYDROXYTRYPTAMINE CONTENT OF THE SMALL INTESTINE AND OTHER ORGANS IN RATS AND MICE
Author(s) -
SULLIVAN T. J.
Publication year - 1961
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1961.tb00301.x
Subject(s) - neomycin , antibiotics , spleen , small intestine , pharmacology , biology , endocrinology , medicine , chemistry , microbiology and biotechnology
Rats and mice were given antibiotics orally and by subcutaneous injection and the effects on tissue levels of 5‐hydroxytryptamine and intestinal bacteria were studied. In mice it was found that antibiotics which caused a large reduction in the bacterial flora of the intestine when given orally also caused a significant increase in intestinal 5‐hydroxytryptamine. In rats, neomycin caused a reduction in the urinary excretion of 5‐hydroxyindoleacetic acid. In both rats and mice, many antibiotics caused a significant reduction in the weight of the spleen.