Premium
THE ANTI‐ANAPHYLACTIC AND HISTAMINE‐RELEASING PROPERTIES OF THE ANTIHISTAMINES. THEIR EFFECT ON THE MAST CELLS
Author(s) -
MOTA I.,
SILVA W. DIAS
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01262.x
Subject(s) - histamine , mast cell , anaphylaxis , chemistry , pharmacology , histamine h4 receptor , histamine h2 receptor , histamine receptor , receptor , histamine h1 receptor , immunology , medicine , allergy , biochemistry , antagonist
It has been shown that, depending upon their concentration, antihistamines act in three different ways: ( a ) by competitive inhibition of histamine as already known; ( b ) by destroying mast cells and releasing histamine; and ( c ) by preventing mast cell damage and histamine release in anaphylaxis. Furthermore, antihistamines potentiated mast cell damage and histamine release by compound 48/80, when acting on guinea‐pig tissues, and inhibited these same phenomena when acting on rat tissues. It is concluded that the effect of antihistamines in anaphylaxis is possibly due both to their competitive inhibition of histamine on smooth muscle receptors and to their inhibition of mast cell damage and histamine release by antigen.