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THE EFFECT OF ENZYME INHIBITORS ON HISTAMINE CATABOLISM IN MAN
Author(s) -
LINDELL S. E.,
NILSSON KAREN,
ROOS B.E.,
WESTLING H.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01255.x
Subject(s) - iproniazid , histamine , catabolism , histamine n methyltransferase , chemistry , enzyme , endocrinology , medicine , pharmacology , biochemistry , monoamine oxidase , histamine h2 receptor , receptor , antagonist
The catabolism of histamine was studied in three female psychiatric patients by analysis of the [ 14 C]‐labelled metabolic products occurring in the urine after a subcutaneous injection of [ 14 C]histamine. Each patient was studied before and during treatment with aminoguanidine or iproniazid. Without treatment the patients had a normal histamine catabolism. Aminoguanidine and iproniazid inhibited the oxidation of histamine to imidazoleacetic acid; iproniazid produced a 50% inhibition of the oxidation of methylhistamine to methylimidazoleacetic acid. After iproniazid a large proportion of the injected [C 14 ]histamine was excreted as methyl [ 14 C]histamine.