Premium
THE EFFECT OF TEMPERATURE ON THE DIRECT MUSCLE TWITCH RESPONSE AND THE ACTION OF DRUGS ON THE ISOLATED DENERVATED RAT DIAPHRAGM
Author(s) -
LETLEY E.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01254.x
Subject(s) - decamethonium , denervation , acetylcholine , diaphragm (acoustics) , medicine , chemistry , contracture , endocrinology , potassium , anatomy , surgery , physics , organic chemistry , acoustics , loudspeaker
The effect of temperature on the direct twitch response of the normal and denervated rat diaphragm, and the sensitivity of the contractural response of the denervated muscle to acetylcholine, suxamethonium, decamethonium, and potassium salts, was studied. Cooling the normal diaphragm from 39 to 20° increased the size of the direct twitch, but below this temperature the twitch response of the muscle was progressively depressed. The denervated muscle twitch was, by contrast, maximal at 39° and decreased as the temperature was lowered. This property of the denervated muscle first appeared about the third day after denervation. The contractural response of the denervated diaphragm to applied acetylcholine was enhanced by cooling, while the response to potassium salts was depressed. The depression of the contracture induced by potassium followed closely the depression of the direct muscle twitch of the denervated muscle over the same temperature range.