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POTENTIATION OF SULPHADIMIDINE BY 2,4‐DIAMINO‐6,7‐DI‐ISOPROPYLPTERIDINE AND OTHER 6,7‐DISUBSTITUTED 2,4‐DIAMINOPTERIDINES AGAINST EIMERIA INFECTIONS OF CHICKS
Author(s) -
HORTONSMITH C.,
LONG P. L.,
COLLIER H. O. J.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01248.x
Subject(s) - sulfadimidine , eimeria , long term potentiation , sulfanilamide , coccidiostats , chemistry , pharmacology , potentiator , coccidiosis , biology , veterinary medicine , biochemistry , medicine , microbiology and biotechnology , chromatography , receptor
Six 2,4‐diaminopteridines substituted in the 6 and 7 positions were tested as potentiators of sulphadimidine against Eimeria tenella . 2,4‐Diamino‐6,7‐di‐isopropylpteridine and 2,4‐diamino‐1′‐propylindolo(2′,3′: 6,7)pteridine were selected for further study. Both potentiated sulphadimidine against E. tenella and the di‐isopropylpteridine potentiated it against E. necatrix . A 10% mixture of the di‐isopropylpteridine with sulphadimidine (or other sulphonamides) appears to offer advantages in the treatment of E. tenella and still more of E. necatrix .