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THE EXCRETION AND STABILITY TO METABOLISM OF BRETYLIUM
Author(s) -
DUNCOMBE W. G.,
McCOUBREY A.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01241.x
Subject(s) - excretion , bretylium , metabolism , endocrinology , medicine , chemistry , physiology , pharmacology , receptor , adrenergic
Bretylium ( o ‐bromobenzylethyldimethylammonium) is a new type of hypotensive drug. It was estimated in extracts of human urine as the methyl orange complex. From 7 to 45% of a single oral dose was found in human urine within 9 hr. The [ 14 C] labelled drug was used to investigate excretion by cats. A minor proportion of a subcutaneous dose was eliminated by cats in the faeces, probably after secretion into the bile. Most of the dose was excreted unchanged in the urine. No products of metabolism were found in either human or cat urine. The drug suffered negligible change when incubated with rat liver tissue in vitro .