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A GANGLION‐STIMULATING PRINCIPLE PRESENT IN PEPTONE
Author(s) -
BERALDO W. T.,
ZANOTTO A.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01235.x
Subject(s) - hexamethonium , atropine , ileum , guinea pig , pepsin , chemistry , trypsin , stimulation , endocrinology , medicine , acetylcholine , amylase , sodium , biochemistry , biology , enzyme , organic chemistry
One of us (W. T. B.) has previously described a pressor effect of peptone in the rat. This effect was considered secondary to a release of sympathin by the stimulation of sympathetic ganglia. The present experiments show that peptone causes contraction of guinea‐pig ileum and inferior eyelid of the rat which is antagonized by hexamethonium. Atropine inhibits equiactive doses of peptone and acetylcholine on the guinea‐pig ileum and eserine potentiates them. Boiling peptone in concentrated hydrochloric acid or n sodium hydroxide destroys its activity; incubation with proteolytic enzymes (trypsin, pepsin, and chymotrypsin) has no effect on its activity. It is concluded that peptone acts upon the intramural ganglia of the guinea‐pig ileum and on sympathetic ganglia which supply the inferior eyelid of the rat.