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THE GANGLION‐BLOCKING ACTIVITY OF AMINOBICYCLO‐[2,2, 1]HEPTANES (CONGENERS OF MECAMYLAMINE) AND BICYCLO[3,2, 1]AZAOCTANES (BRIDGED CONGENERS OF PEMPIDINE)
Author(s) -
EDGE N. D.,
CORNE S. J.,
LEE G. E.,
WRAGG W. R.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01232.x
Subject(s) - mecamylamine , blocking (statistics) , bicyclic molecule , neuroscience , pharmacology , chemistry , antagonist , medicine , stereochemistry , psychology , computer science , receptor , computer network
The structural requirements for strong ganglion‐blocking activity and long duration of action amongst some lower homologues of mecamylamine, together with the discovery of similar activities amongst isomers with enlarged ring structures, are described. In both series of compounds it was found that the successive introduction of C ‐methyl groups surrounding the nitrogen atom resulted in a progressive increase in ganglion‐blocking activity and duration of action.