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EFFECTS OF RESERPINE, CHLORPROMAZINE AND SODIUM SALICYLATE ON THE ENZYMIC ACTIVITY OF RAT LIVER
Author(s) -
KIRPEKAR S. M.,
LEWIS J. J.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01228.x
Subject(s) - reserpine , oxidative phosphorylation , chlorpromazine , sodium salicylate , chemistry , atpase , pharmacology , biochemistry , stimulation , in vitro , depressant , dinitrophenol , endocrinology , enzyme , biology , organic chemistry
The effects of reserpine, chlorpromazine and sodium salicylate on oxidative phosphorylation, stimulation of glutamic acid oxidation and adenosinetriphosphatase activity have been compared in vitro with those of 2,4‐dinitrophenol using rat liver preparations. All three drugs inhibit oxidative phosphorylation, slightly stimulate glutamic acid oxidation and stimulate adenosine‐triphosphatase activity at high concentrations. Reserpine has no effect on adenosinetriphosphatase activity. It is suggested that the characteristic depressant effects of reserpine on isolated tissues in vitro may be due to interference with production of energy by oxidative phosphorylation.