Premium
THE EFFECTS OF INTRACISTERNAL SARIN AND PYRIDINE‐2‐ALDOXIME METHYL METHANESULPHONATE IN ANAESTHETIZED DOGS
Author(s) -
BROWN R. V.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01227.x
Subject(s) - sarin , atropine , oxime , chemistry , anesthesia , pralidoxime , pharmacology , medicine , acetylcholinesterase , biochemistry , enzyme
Dogs poisoned by the anticholinesterase sarin could be saved by intravenous administration of atropine sulphate together with a suitable oxime. The central effects of intracisternal sarin were respiratory paralysis and vasomotor stimulation. The problem arose as to whether the oxime, being a quaternary nitrogen compound, could enter the brain from the blood, and could have a central action on the paralysed respiration. The methyl methanesulphonate of pyridine‐2‐aldoxime administered intracisternally, after sarin poisoning by the same route, was ineffective; atropine, given intravenously, was effective. The central and peripheral effects of sarin were thus reversed by the atropine‐oxime therapy, the central effects by atropine, the peripheral by the oxime.