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ACTION OF TWO ETHYL THIOL ESTERS AGAINST EXPERIMENTAL TUBERCULOSIS IN THE GUINEA‐PIG
Author(s) -
DAVIES G. E.,
DRIVER G. W.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb01219.x
Subject(s) - guinea pig , thiol , pharmacology , chemistry , action (physics) , tuberculosis , new guinea , biochemistry , traditional medicine , medicine , endocrinology , pathology , history , physics , ethnology , quantum mechanics
Two thiol esters, ethyl dithiolterephthalate (Compound 13,130) and ditophal (ethyl dithiolisophthalate; Etisul), have been tested for their antituberculosis activity in guinea‐pigs. Compound 13,130 was active at a dose of 100 mg./kg. twice daily by mouth in animals infected subcutaneously, but was inactive against an intracerebral infection at 50 mg./kg. Ditophal was active in the subcutaneously infected animals at 200 mg./kg. orally or 50 mg./kg. subcutaneously. Higher doses subcutaneously were irritant.