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THE MECHANISM OF THE INHIBITORY EFFECT OF GLUTEN FRACTIONS ON THE PERISTALTIC REFLEX
Author(s) -
SCHNEIDER R.,
BISHOP HILARY
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb00285.x
Subject(s) - acetylcholine , peristalsis , chemistry , stimulation , cholinergic , reflex , inhibitory postsynaptic potential , guinea pig , jejunum , atropine , chromatography , pharmacology , endocrinology , medicine , biochemistry
The mechanism of the inhibitory effect of gluten fractions on the peristaltic reflex was studied using, first, a filtrate of the autoclaved peptic‐tryptic digest of gluten (fraction III A.F.) and, second, the ultrafiltrate of an aqueous extract of gluten (fraction G.U.F.). The fractions did not act as antagonists to naturally‐occurring agents such as acetylcholine or substance P, but they did depress the twitch response of the isolated guinea‐pig jejunum preparation stimulated coaxially. The output of acetylcholine from cholinergic nerve endings in gut was decreased during rest as well as during electrical stimulation. In large amounts, the gluten fractions depressed acetylcholine synthesis in vitro . It was concluded that the mechanism of inhibition of the peristaltic reflex gluten fractions was chiefly by decreasing acetylcholine release.