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SOME PHARMACOLOGICAL ACTIONS OF SYNTHETIC ANALOGUES OF ANGIOTENSINAMIDE
Author(s) -
PAIVA THEREZINHA B.,
PAIVA A. C. M.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb00281.x
Subject(s) - peptide , potency , ileum , pharmacology , chemistry , biological activity , guinea pig , angiotensin ii , uterus , biochemistry , biology , endocrinology , in vitro , receptor
In order to evaluate the importance of some structural features of asparagyl 1 ‐valyl 5 ‐angiotensin II (angiotensinamide) for its pharmacological actions, the relative potencies of angiotensinamide and five peptide analogues were studied on the blood pressure of the rat, the isolated rat uterus and the isolated guinea‐pig ileum. All the modifications of the angiotensinamide structure that were studied led to a decrease of potency which, however, was not the same on all three preparations. The importance of the guanido group, the phenolic group and the length of the peptide chain for the pharmacological activities of these peptides is discussed.