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A STUDY OF POTENTIAL HISTIDINE DECARBOXYLASE INHIBITORS
Author(s) -
MACKAY D.,
SHEPHERD D. M.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb00279.x
Subject(s) - histidine decarboxylase , imidazole , histidine , chemistry , potency , stereochemistry , alpha (finance) , enzyme , biochemistry , ring (chemistry) , structure–activity relationship , beta (programming language) , aromatic l amino acid decarboxylase , pharmacology , in vitro , biology , medicine , organic chemistry , computer science , programming language , patient satisfaction , construct validity , nursing
A series of compounds has been examined for ability to inhibit histidine decarboxylase. Histidine analogues having substituents in the imidazole ring showed a wide variation in potency, but these were all much less active than α‐methyldopa [β‐(3,4‐dihydroxyphenyl)‐α‐methylalanine], the most potent known inhibitor of histidine decarboxylase. Some tentative conclusions are drawn regarding the relationship between chemical structure and inhibitory activity.