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THE ANTICHOLINESTERASE ACTIVITY OF SOME ANTIADRENALINE AGENTS
Author(s) -
BOYD HELEN,
CHANG V.,
RAND M. J.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb00275.x
Subject(s) - vas deferens , hypogastric nerve , phenoxybenzamine , yohimbine , stimulation , tolazoline , cholinergic , pharmacology , medicine , chemistry , endocrinology , antagonist , propranolol , receptor
The contractions of the isolated guinea‐pig vas deferens in response to stimulation of the sympathetic hypogastric nerve were potentiated by low concentrations and inhibited by high concentrations of the antiadrenaline agents tolazoline, yohimbine, ergotamine, phenoxybenzamine and piperoxan. Eserine potentiated the contractions of the vas deferens produced by hypogastric nerve stimulation. The cholinesterase activity of an extract of vas deferens was decreased by the antiadrenaline agents. The potentiation of responses to sympathetic stimulation by antiadrenaline drugs, which also possess anticholinesterase activity, can be explained on the basis of a cholinergic sympathetic mechanism.