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NEUROMUSCULAR BLOCKADE BY STREPTOMYCIN AND DIHYDROSTREPTOMYCIN
Author(s) -
JINDAL M. N.,
DESHPANDE V. R.
Publication year - 1960
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1960.tb00271.x
Subject(s) - dihydrostreptomycin , streptomycin , neuromuscular blockade , medicine , anesthesia , microbiology and biotechnology , antibiotics , biology
Both streptomycin and dihydrostreptomycin in large doses produced neuromuscular blockade in different types of skeletal nerve‐muscle preparations. Streptomycin had a quicker, more marked and a longer‐lasting action than dihydrostreptomycin. Neostigmine reversed a partial block of streptomycin, but a complete neuromuscular block remained unaffected. Calcium ions antagonized the neuromuscular block of streptomycin rapidly but incompletely.