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THE EFFECT OF METHYLPENTYNOL AND METHYLPENTYNOL CARBAMATE ON THE PERFUSED SUPERIOR CERVICAL GANGLION OF THE CAT
Author(s) -
MARLEY E.,
PATON W. D. M.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb01401.x
Subject(s) - acetylcholine , superior cervical ganglion , ganglion , carbamate , chemistry , pharmacology , endocrinology , anesthesia , medicine , anatomy , biochemistry
The action of methylpentynol and methylpentynol carbamate on the perfused superior cervical ganglion of the cat was analysed. Both drugs, in doses of 1 to 5 mg., depressed the output of acetylcholine. If the acetylcholine output was reduced by more than about 50%, transmission failed. Both drugs also reduced the response of the ganglion to injected acetylcholine. The carbamate, but not methylpentynol itself, had a transient stimulant action on the ganglion, unaccompanied by acetylcholine release.