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CARDIOVASCULAR EFFECTS OF INTRAVENOUS INFUSIONS OF 5‐HYDROXYTRYPTAMINE IN MAN
Author(s) -
LeMESSURIER D. H.,
SCHWARTZ C. J.,
WHELAN R. F.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb01393.x
Subject(s) - dilator , forearm , medicine , heart rate , blood flow , blood pressure , anesthesia , intravenous infusions , cardiology , surgery
Intravenous infusions of 5‐hydroxytryptamine creatinine sulphate in doses of 1,2, and 3 mg./min. of the salt into 42 normal subjects caused a dilator response of the forearm vessels, consisting of an initial transient increase in flow usually followed by a smaller but sustained increase. A fall in forearm flow was not seen. Heart rate was invariably increased and the increase preceded other changes by 10 to 20 sec. suggesting a direct effect on the heart. The sustained increase in flow probably represents a balance between the direct constrictor action of the drug and a secondary dilator effect. The blood pressure response was variable and it appeared unlikely that it was responsible for more than a small part of the forearm flow changes. Two subjects appeared to be abnormally sensitive to the drug.