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THE STABILITY OF ENDOGENOUS CORTICOTROPHIN IN RAT BLOOD IN VITRO
Author(s) -
HODGES J. R.,
VERNIKOS JOAN
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb01386.x
Subject(s) - endogeny , in vitro , endocrinology , medicine , whole blood , blood plasma , chemistry , biochemistry
Endogenous corticotrophin is stable in blood in vitro for periods of up to 1 hr. at 4° and 22°, and in plasma for at least 24 hr. at −15°. Estimates of plasma corticotrophin concentration provide less consistent results than assays done on whole blood. The optimal conditions for storing blood prior to the determination of its corticotrophin concentration are discussed.