Premium
THE RELATION BETWEEN TEMPERATURE AND CHANGES IN ION CONCENTRATION ON VENTRICULAR FIBRILLATION INDUCED ELECTRICALLY
Author(s) -
MILTON A. S.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb01381.x
Subject(s) - ventricular fibrillation , potassium , calcium , fibrillation , sodium , medicine , stimulation , chemistry , cardiology , endocrinology , anesthesia , atrial fibrillation , organic chemistry
Further observations have been made on ventricular fibrillation induced by electrical stimulation in the isolated rabbit heart, in extension of the finding that fibrillation was arrested by cooling from 37° to 32°. The observations now made suggest that at 37° the isolated rabbit heart perfused with Locke solution is on the edge of anoxia, but that at 32° the oxygen supply is adequate. At the lower temperature the proportion of hearts fibrillating at any given potassium concentration was reduced, so, although the proportion of hearts fibrillating rose as the potassium concentration fell, even when the latter was one‐quarter of the normal the proportion was not higher than 67%. The relation of the concentration of calcium ions to the proportion of hearts fibrillating changed from biphasic at 37° to almost rectilinear at 32°, the proportion increasing as the concentration of calcium ions rose. It was confirmed that a reduction in sodium concentration also raises the proportion of hearts fibrillating.