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THE DURATION OF ACTION OF SOME CARDIAC GLYCOSIDES AND AGLYCONES IN THE GUINEA‐PIG
Author(s) -
RAND M.,
STAFFORD ANNE
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb01379.x
Subject(s) - digitoxigenin , digitoxin , digoxigenin , digoxin , pharmacology , ouabain , digitalis , cardenolide , chemistry , guinea pig , glycoside , duration (music) , medicine , biochemistry , sodium , stereochemistry , heart failure , in situ hybridization , gene expression , literature , art , gene , organic chemistry
A method is described for determining the duration of action of cardiac glycosides and aglycones in the guinea‐pig. It is based on their property of potentiating the cardiac response to adenosine. The method is particularly suitable for those drugs with a short duration of action, whereas previous methods are more suitable for those drugs with longer durations of action. The duration of action of one‐fifth of the lethal dose has been found for: digoxigenin, lanatoside C, ouabain, digitoxigenin‐3‐one, digitoxin, 3‐acetyldigitoxigenin, digoxin, digitoxigenin, lanatoside A; these drugs are arranged in order of increasing duration of action. The possible relationship between the elimination of these drugs and their duration of action can provide an estimate of their rates of elimination.