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INCREASE OF 5‐HYDROXYTRYPTAMINE IN THE RAT BRAIN BY RAUNESCINE
Author(s) -
PAASONEN M. K.,
KÄRKI N. T.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb01377.x
Subject(s) - iproniazid , medicine , endocrinology , serotonin , chemistry , pharmacology , biochemistry , monoamine oxidase , receptor , enzyme
The Rauwolfia alkaloid raunescine (5 mg./kg., intraperitoneally) increased the concentration of 5‐hydroxytryptamine in the brains of rats after iproniazid pre‐treatment. This was evident 3 to 4 hr. after raunescine administration. There was no general increase in the noradrenaline content of the brains. In the intestine, raunescine depleted the 5‐hydroxytryptamine content by about 50% within 3 to 4 hr. if the animals had been pre‐treated with iproniazid. Iproniazid did not increase the content of noradrenaline in the intestine.