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COMPARISON OF EFFECTS OF VALYL 3 — OXYTOCIN AND SYNTOCINON ON THE CARDIOVASCULAR SYSTEM OF MAN
Author(s) -
KITCHIN A. H.,
KONZETT H.,
PICKFORD MARY
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00965.x
Subject(s) - oxytocin , circulatory system , vasopressin , vasodilation , medicine , blood pressure , blood flow , anesthesia
Valyl 3 ‐oxytocin has similar circulatory effects in man to those of Syntocinon (synthetic oxytocin). On intravenous administration, it caused a rise in limb blood flow and in pulse rate and a fall in blood pressure. It had a direct vasodilator effect on limb blood vessels. Valyl 3 ‐oxytocin was 1.5 to 2 times more potent than Syntocinon in terms of its circulatory effect in man. The circulatory effects of valyl 3 ‐oxytocin were less readily antagonized by vasopressin than are those of Syntocinon.