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ANTAGONISM OF THE EFFECTS OF TREMORINE BY TROPINE DERIVATIVES
Author(s) -
FARQUHARSON MURIEL E.,
JOHNSTON R. G.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00964.x
Subject(s) - antagonism , pharmacology , chemistry , medicine , receptor
Methods of testing new drugs for anti‐Parkinson activity are briefly reviewed. The production in animals of Parkinson‐like effects by Tremorine (1,4‐dipyrrolidin‐1′‐ylbut‐2‐yne), and the inhibition of these effects in mice by a number of tropine derivatives, are described. No correlation was found between the activity against tremor and the anticholinergic, antihistaminic or local anaesthetic properties of the compounds.