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THE USE OF THE GUINEA‐PIG ILEUM PREPARATION FOR TESTING THE ACTIVITY OF SUBSTANCES WHICH IMITATE OR ANTAGONIZE THE ACTIONS OF 5‐HYDROXYTRYPTAMINE AND TRYPTAMINE
Author(s) -
BARLOW R. B.,
KHAN I.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00963.x
Subject(s) - phenoxybenzamine , ileum , guinea pig , receptor , uterus , chemistry , pharmacology , 5 ht receptor , serotonin , endocrinology , morphine , medicine , biology , biochemistry
On the guinea‐pig ileum, 5‐hydroxytryptamine appeared to act in the same way as tryptamine on two types of receptor (morphine‐sensitive and phenoxybenzamine(Dibenzyline)‐sensitive). The actions of analogues of 5‐hydroxytryptamine on the phenoxybenzamine‐sensitive receptors resembled their actions on the rat uterus, and the actions on the morphine‐sensitive receptors slightly resembled those on the rat fundus strip. The guinea‐pig ileum preparation, however, did not appear to be more suitable than the rat uterus and rat fundus strip for testing the ability of compounds to imitate or antagonize 5‐hydroxytryptamine.