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DRUG RESISTANCE IN TRYPANOSOMES; EFFECTS OF METABOLIC INHIBITORS, p H AND OXIDATION‐REDUCTION POTENTIAL ON NORMAL AND RESISTANT TRYPANOSOMA RHODESIENSE
Author(s) -
WILLIAMSON J.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00948.x
Subject(s) - trypanocidal agent , drug , drug resistance , trypanosoma brucei rhodesiense , pharmacology , biology , trypanosoma , enzyme , in vitro , suramin , diminazene , trypanosomiasis , trypanosoma brucei , biochemistry , microbiology and biotechnology , african trypanosomiasis , virology , gene
A wide variety of metabolic inhibitors tested in vitro for trypanocidal activity on normal and drug‐resistant strains of Trypanosoma rhodesiense showed no relation between acquired drug resistance and changes in specific enzymatic function. Oxidation‐reduction potential is an important factor in trypanocidal action but is not obviously related to the development of resistance. The dependence on p H of the trypanocid action of ionizing drugs against both normal and resistant trypanosomes supports the postulate that the development of resistance involves physical changes in cell structures associated with the uptake of drug.