Premium
TRACER STUDIES OF THE DISTRIBUTION AND TRYPANOCIDAL ACTION OF STILBAMIDINE IN RATS
Author(s) -
FULTON J. D.,
MATHEW K. K.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00940.x
Subject(s) - distribution (mathematics) , drug , pharmacology , trypanosomiasis , drug action , mechanism of action , chemistry , biology , medicine , in vitro , pathology , biochemistry , mathematical analysis , mathematics
[ 14 C]Stilbamidine was used to study the distribution of the drug in the organs and tissues of rats following intravenous injection. The prophylactic action of stilbamidine was shown to depend upon the unchanged drug retained in tissues, especially the liver. Only the parent drug was extracted from trypanosomes when an infection was treated during the acute phase, as shown by the use of the fluorescent properties of stilbamidine in conjunction with scanning and chromatographic techniques. The action of stilbamidine on trypanosomes is therefore a direct one. A method for the synthesis of [ 14 C]stilbamidine in much improved yield is also described.