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THE EXTRACTION OF HUMAN URINARY KININ (SUBSTANCE Z) AND ITS RELATION TO THE PLASMA KININS
Author(s) -
GADDUM J. H.,
HORTON E. W.
Publication year - 1959
Publication title -
british journal of pharmacology and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0366-0826
DOI - 10.1111/j.1476-5381.1959.tb00937.x
Subject(s) - kinin , kallidin , bradykinin , urinary system , chemistry , chromatography , substance p , kallikrein , endocrinology , medicine , biochemistry , neuropeptide , enzyme , receptor
Human urinary kinin (substance Z) has been extracted by modifications of the methods previously described by Gomes (1955) and Jensen (1958). The separation of two oxytocic fractions from such extracts by paper pulp chromatography (Walaszek, 1957; Jensen, 1958) could not be confirmed. Substance Z could not be distinguished from kallidin, bradykinin or glass‐activated kinin by parallel quantitative assays, thus confirming that these four substances are very closely related.